Vitamins and Minerals in the Prevention and Treatment of Cancer

Description

This book provides researchers and practitioners with a unique collection of current research on the role of vitamins and micronutrients in cancer prevention and treatment. New theories are discussed including a hypothesis that dietary factors may protect against genetically predisposed cancers. Mechanisms by which different vitamins and minerals appear to inhibit carcinogenesis or cell transformation are described including vitamins A C E and selenium protection against oxidative stress by induction of enzymes as catalase and dismutase or inteference with free radical mechanisms; organosulfur compound inhibition of P450 activation enzymes or enhancement of detoxification enzymes; metal ion effects in the modulation of gene expression by site-specific binding of Zn-finger loop domains; B-carotene metabolite up-regulation of gap junctional communication between cells; and vitamin D3 elimination of amplified oncogenes or drug resistant genes. The book also reviews literature implicating a possible relationship between potassium and the control of cancer. Other information presented includes a discussion of contemporary technologies and data associating lipotrope deficiencies with alterations in xenobiotic metabolism nucleic acid methylation purine and pyrimidine synthesis signal transduction and chromosome anomalies. | Vitamins and Minerals in the Prevention and Treatment of Cancer